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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are often described by their focus on practical aspects of study design which include the recruitment process and consent, adhering and the use of standard equipment.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and lessen the chance of bias, 프라그마틱 무료게임 is also necessary. However too much heterogeneity could result in issues with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They also provide a useful method of determining the causal relationship between an intervention and its outcomes. However, they shouldn't be used to substitute for explanatory trials.

The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study, including recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the subject of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.